| Name | Episode(s) | Description |
| Allison | "Is It Fall Yet?" | Bisexual art colony student that tried to put the moves on Jane when she was vulnerable. |
| Amanda Lane | "Lane Miserables" "Art Burn" |
Mother of Jane and fellow artist. Hard-core believer in the "butterfly" theory. |
| Artie | "Esteemsters" "The Lawndale File" "A Tree Grows In Lawndale" |
Pimple-faced teenager obsessed with the notion that he was abducted by aliens. |
| Aunt Amy | "I Don't" "Through A Lense Darkly" "Aunt Nauseam" |
Helen's sister and Daria's, dare I say, "cool" aunt. Basically, she'd be Daria's much older identical twin, if that were possible. |
| Aunt Rita | "I Don't" "Aunt Nauseam" |
Helen's other sister. Goes through boyfriends faster than Quinn goes through eyeliner. |
| Axl | "Pierce Me" | Piercing/tattoo artist on Dega Street. Seems cool but I don't believe I'd trust him with a sharp needle near ANY of my body parts. |
| Cheerleaders | "The F Word" | Angie, Lisa, and Nicki. Brit's fellow, pom-pom wavers. Angie and Lisa also spoke in "Daria Dance Party." |
| Courtney & Adrian | "Lane Miserables" | Two of Summer's four kids. The two that aren't out roaming the streets or hitch-hiking to Vegas. |
| Coyote & Willow | "That Was Then, This Is Dumb" | There's nothing more pathetic than a football player trying to think...except perhaps a pair of middle-aged hippies. |
| David Sorensen | "Is It Fall Yet?" | Self-proclaimed egghead hired to tutor Quinn during the summer. Proves to Quinn that looks really AREN'T everything. |
| Dr. Shar | "Too Cute" | Plastic surgeon. Makes her money by chipping away at the self-esteem of young girls. |
| Eric Shrecter | "Pierce Me" "Daria!" "Psycho Therapy" |
Helen's over-stressed, over-worked boss. The two of them are SO perfect for each other. Jake better look out! |
| Grandma Ruth | "Jake Of Hearts" | Jakey's mommy. Even more pushy than Helen. Who knew such a thing was possible? |
| Holidays | "Depth Takes A Holiday" | Halloween, Christmas, Guy Fawkes Day, St. Patrick's Day, and Cupid. What can I say about these guys that hasn't already been said? |
| Lane Siblings | "Lane Miserables" | Sisters Summer and Penny. Brother Wind. Jane and Trent are the NORMAL ones! Wind also had a speaking role in "Art Burn." |
| Lehrman | "I Don't" | Anti-social, monotoned groomsman at Daria's cousin's wedding whom Daria is paired up with for the ceremony. |
| Monique | "Pierce Me" "Lane Miserables" |
Member of The Harpies. On/off girlfriend of Trent. |
| Mrs. Johanssen | "Cafe Disaffecto" "The Old And The Beautiful" "Mart Of Darkness" |
The rather large hypoglycemic in the flowered moo-moo. Has an obsession for chocolate, even though her doctor warned her against it. |
| Ms. Morris | "See Jane Run" | Lawndale High's corrupt gym teacher/track coach. Has an ax to grind with the Lane family. |
| Tad & Tricia Guptey | "Pinch Sitter" "I Loathe A Parade" |
The ideally perfect children...until Daria and Jane warped their impressionble little minds. |
| Ted Dewit-Clinton | "The New Kid" "I Loathe A Parade" |
Daria's ALMOST boyfriend for a brief moment...until he became interesting. |
| Teresa | "Daria!" "The Old And The Beautiful" "A Tree Grows In Lawndale" |
Salesperson at Junior 5. Shunned by the Fashion Club for uttering those horrifying words: SALE RACK! |
| Tommy Sherman | "The Misery Chick" | Arrogant, self-centered ex-football star whose return to Lawndale High was short-lived. |
| Val | "The Lost Girls" | Owns her own teen fashion magazine. Teenager trapped in a thirty-something body. |
| Vincent Lane | "Lane Miserables" "Art Burn" |
The ever-elusive father of Jane and Trent. Spends most of his time travelling and photographing rock formations. |